FISIOGENÓMICA

porque cada día empieza una nueva aventura

QUÉ ES FISIOGENÓMICA?



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Este espacio online ha nacido con la intención de compartir nuestra experiencia y conocimientos en el ámbito de la fisiogenómica y la nutrición aplicada a la salud. El alimento puede funcionar como un nutriente o como un tóxico en nuestro organismo, pudiendo llegar a causar patología o a prevenirnos de ella. La FISIOGENÓMICA es la especialidad que se desarrolla con el fin de mejorar la patología propia de la fisioterapia, teniendo en cuenta cómo influye una nutrición incorrecta en todo el organismo. Curiosamente, mediante esta especialidad conseguimos mejorar esas “dolencias” osteomusculares, mejorando también su energía, su Sistema Inmune y su ¡alegría! Se debe tener en cuenta que una gran parte (la mayoría) de los problemas físicos o dolores tienen su origen en un problema metabólico; por ejemplo una persona con un problema de estreñimiento tendrá una inflamación en el colon y esta inflamación es fácil que se manifieste como un dolor lumbar. Como éste, múltiples ejemplos nos explican dolores crónicos musculares, dolores de tipo artrosis, tendinopatías recurrentes, etc. Habría que analizar cada caso de forma individualizada para llegar a un diagnóstico y ofrecer el tratamiento oportuno. Con esta idea queremos acercar a todo tipo de público, tanto al público de la calle como al profesional sanitario, la ciencia que estudia los genes, la nutrición y la patología. Aquí podréis encontrar todo tipo de artículos, casos clínicos y demás información relacionada, así como tener tu propia consulta online.

Fisiogenómica CLÍNICA



En este espacio se irán mostrando ejemplos en cuanto a sintomatología y posibles protocolos para las distintas patologías más frecuentes en la población.



NUTRICIÓN APLICADA a la PATOLOGÍA

PRONTUARIO

GUÍA de NUTRICIÓN INFANTIL


APUNTES de FISIOGENÓMICA

DIETAS


Test Fisiogenómicos


Relación Viscero-Somática

Lope de Irigoyen, 19 - Entreplanta local 9

C.P. 20302 Irun, Gipuzkoa

+34690726801

+34943575450



DIAGNÓSTICO FISIOGENÓMICO. Si quieres saber tu diagnóstico... Clicka una opción y elige tu aventura!! En primer lugar se debe analizar el dolor y/o problema mediante las preguntas “qué duele”; “cuándo duele”; “cómo duele”; “dónde duele”; “a qué hora duele”

...Animate

Nuestro Equipo

We can satisfy your demand



Itziar González

Itziar González

CREADORA DEL CONCEPTO FISIOGENÓMICA PARA AUNAR FISIOTERAPIA, OSTEOPATÍA, NUTRICIÓN TERAPEUTICA Y NUTRIGENÓMICA.

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Florinda 
                                    Pérez

Florinda Pérez

Fisioterapeuta

A Coruña

(Coruña, 1983); diplomada en Fisioterapia por la Universidad de Vigo desde el 2004, y más enamorada y apasionada de la profesión cada año desde entonces.

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Edgar indurria

Edgar indurria

Nutricionista

Irún (Gipuzkoa)

(Madrid 1985) soy Dietista-Nutricionista (Universidad Autónoma de Madrid), al terminar la diplomatura hice un Máster en Alto Rendimiento Deportivo (Comité Olímpico Español), y actualmente me sigo formando en Nutrigenómica.

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Raúl Cadenas

Raúl Cadenas

Fisioterapeuta

Baiona (Pontevedra

(Vigo, 1982) es fisioterapeuta (Universidad de Vigo), osteópata C.O. (Universidad de Alcalá de Henares y Escuela de Osteopatía de Madrid) Máster en Nutrición (Universidad de Vigo).

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Trabajando con Fisiogenómica



Mercedes

Mercedes Mayor

Fisioterapeuta

Ibiza

(Béjar, Salamanca, 1978) es fisioterapeuta (Universidad de Salamanca), Curso de Nutrición en los procesos de intervención fisioterápica (Universidad de la Coruña), Curso de “Acupuntura y Medicina Tradicional China”

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Jose I. García

Fisioterapeuta

Zaragoza

(Zaragoza 1.971) Diplomado en fisioterapia (E. U. Gimbernat. Barcelona). Master en fisioterapia del deporte (E. U. Gimbernat). Asistencia a numerosos cursos y congresos de terapia manual, regeneración de partes blandas, nutrición, deporte

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Lucía Ballesteros

Fisioterapeuta especializada en Pelviperineología

Santander

Soy Lucía y trabajo junto con mi hermana Raquel en una consulta propia en Santander, Fisioterapia Ballesteros . Aquí podemos desarrollar plenamente una profesión que nos apasiona, así como disfrutar del entorno natural que nos rodea y tanto nos gusta.

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Ane Daza

Fisioterapeuta

Irún (Gipuzkoa)

(Donostia-Gipuzkoa-1977) es fisioterapeuta (Universidad de Salamanca), especializada en terapia Manual Osteopática 1º y 2º (Escuela Osteopátia de Madrid), Fibrólisis Miofascial Instrumental (Fisioformación)

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Mónica MartÍn de Mingo

Fisioterapeuta

Tordesillas (Valladolid)

(Barakaldo-Vizcaya 1978) Diplomada en fisioterapia (Universidad de Salamanca 1999) Master en Metodología Osteopática (Universidad Europea de Madrid) Formada en Inducción miofascial, terapia cráneo- sacral Upleged, tratamiento de patología del lactante (Cólicos, reflujo, torticolis), neurodinamia.

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Sandra Fernández Velasco

Fisioterapeuta

Móstoles (Madrid)

(1983) Fisioterapeuta (URJC 2004) y Osteopata C.O. (EOM 2010). Experimentada en vendaje neuromucular y terapia Cráneo-Sacra tras muchos años unida a estas terapias. Conocimientos en posturologia, auriculoterapia, reeducación postural global y endocrinología. Experta en fisiogenomica.

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Iraida Thais Díaz Sosa

Fisioterapeuta

Las Palmas de Gran Canaria

(Las Palmas de Gran Canaria, 1983). Diplomada en Fisioterapia (Universidad Alfonso X El Sabio), en su formación a lo largo de más de 10 años, cuenta con diversos posgrados: Fisioterapia Perineal Integral; Ftp. Uroginecológica, Ftp. Obstétrica, Ftp. Coloproctológica,

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Nazareth Moreno García

Fisioterapeuta y Osteópata

Granada

Diplomada en Fisioterapia por la Universidad de Granada. Osteópata C.O por la Escuela de osteopatía de Madrid. Lo que más disfruto tratando es suelo pélvico , embarazadas, bebes y osteopatía visceral.

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Mariana Carretero Carretero

Licenciada en Medicina y Cirugía. Especialista en Anestesiología y Reanimación. Especialista en Medicina Estética

Almendralejo (Badajoz)

Tras realizar el curso “Importancia de la nutrición en la patología osteomuscular” se adentra de lleno en el mundo de la Fisiogenómica.

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Alexandra de la Mata López

Fisioterapeuta

Fuenlabrada (Madrid)

Fisioterapeuta por la Universidad Rey Juan Carlos y Osteópata C.O. por la EOM. Especialista en fisiogenómica. Formada en posturología, punción seca, sistema endocrino, auriculoterapia y vendaje neuromuscular. Voy buscando las herramientas que me permitan ayudar a mis pacientes a sentirse bien

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Localiza tu Fisiogenómico mas cercano











Nuestros Cursos

La fisiogenómica es la ciencia que se ha creado para aunar los beneficios de la nutrigenómica y dieta personalizada, en función del perfil bioquímico individual, con el fin de solucionar o mejorar las lesiones musculoesqueléticas y todos aquellos problemas que se tratan en osteopatía y fisioterapia. Mediante la siguiente formación la intención es la de crear Expertos en utilizar las herramientas nutricionales precisas para cada patología y para cada persona en función de su sintomatología, antecedentes personales, semiología y posibilidades, con el último objetivo de conseguir una calidad de vida óptima. Para conseguir dominar todos los posibles aspectos que alteran la bioquímica, se trataran en profundidad la problemática bioquímica, visceral e inmunitaria aplicada en nuestro trabajo. Y se dedicará parte de la formación a enfatizar situaciones especiales como el embarazo, la infancia o el deporte, ya que los requerimientos nutricionales son diferentes.



cursos 2019


Fechas 2019 Ciudad Tipo de Curso Organizado Contacto Inscripción
11-13 Enero Toledo Básico II UCLM (SUNSI) asuncion.ferri@uclm.es
25-27 Enero Ibiza Básico por Raúl Cadenas Colegio de Fisioterapèutas de Baleares formacioncolfisiobalear@gmail.com
25-27 Enero Madrid Nutrigenómica en los procesos de intervención en terapia manual. Módulo 1 Seminario 1 EORA (María Dolores Mazoteras) postgrados@fbeosteo.com / Tfno. 619855500 Info e inscripción
08-09 Febrero Toledo Básico I UCLM (SUNSI) asuncion.ferri@uclm.es
08-10 Febrero Badajoz NUTRIGENÓMICA COMPLEMENTARIA A LA FISIOTERAPIA GINECOLÓGICA cursos@impul.soservicios.es Web: www.impulsoservicios.es
22-24 Febrero Ibiza Básico por Raúl Cadenas Colegio de Fisioterapèutas de Baleares formacioncolfisiobalear@gmail.com
22-24 Febrero Madrid Nutrigenómica en los procesos de intervención en terapia manual. Módulo 1 Seminario 2 EORA (María Dolores Mazoteras) postgrados@fbeosteo.com / Tfno. 619855500 Info e inscripción
08-10 Marzo Mallorca Básico por Raúl Cadenas Colegio de Fisioterapèutas de Baleares formacioncolfisiobalear@gmail.com
08-10 Marzo Toledo Nutrigenómica complementaria a la Fisioterapia ginecológica (Seminario 1 en curso Especialista) UCLM (SUNSI) asuncion.ferri@uclm.es
22-24 Marzo Girona Bàsico por Raúl Cadenas (Marta) cursoscosfisio@gmail.com Web: www.elbaobab.cat
22-24 Marzo Madrid Nutrición complementaria a la Fisioterapia Deportiva. Módulo 2 EORA (María Dolores Mazoteras) postgrados@fbeosteo.com

+34619855500

Info e inscripción
05-07 Abril Mallorca Básico por Raúl Cadenas Colegio de Fisioterapèutas de Baleares formacioncolfisiobalear@gmail.com
05-07 Abril Toledo Nutrigenómica complementaria a la Fisioterapia ginecológica (Seminario 2 en curso Especialista) UCLM (SUNSI) asuncion.ferri@uclm.es
26 -28 Abril Girona Bàsico por Raúl Cadenas (Marta) cursoscosfisio@gmail.com Web: www.elbaobab.cat
26-28 Abril Madrid Nutrigenómica complementaria a la Fisioterapia ginecológica. Módulo 3 Seminario 1 EORA (María Dolores Mazoteras) postgrados@fbeosteo.com

+34619855500

Info e inscripción
24-26 Mayo Madrid Nutrigenómica complementaria a la Fisioterapia ginecológica. Módulo 3 Seminario 2 EORA (María Dolores Mazoteras) postgrados@fbeosteo.com

+34619855500

Info e inscripción
07-09 Junio Vigo Ginecológia por Raúl Cadenas e Itziar González fisiovalminor@gmail.com

+34609916791 +34986352831

20-22 Septiembre Madrid Intervención nutricional en patología crónica y su aplicación para el profesional sanitario. Módulo 4 EORA (María Dolores Mazoteras) postgrados@fbeosteo.com

+34619855500

Info e inscripción
22 Septiembre Málaga Master por Raúl Cadenas Universidad de Málaga estherdiaz@uma.es
05 Octubre Congreso Nutergia
18-20 Octubre Madrid Nutrición complementaria a la terapia pediátrica. Módulo 6 EORA (María Dolores Mazoteras) postgrados@fbeosteo.com

+34619855500

Info e inscripción
14-15 Noviembre Palencia Básico por Raúl Cadenas Complejo Asistencial Universitario de Palencia (María Teresa) mfernandezgonz@saludcastillayleon.es
16 Noviembre Congreso Nutergia
30 Noviembre Congreso Nutergia

cursos 2020


Fechas 2020 Ciudad Tipo de Curso Organizado Contacto Inscripción
10-12 Enero Toledo Básico I UCLM (SUNSI) asuncion.ferri@uclm.es
24-26 Enero NUTERGIA
07-09 Febrero Toledo Básico II UCLM (SUNSI) asuncion.ferri@uclm.es
13-14 Febrero Palencia Básico por Raúl Cadenas Complejo Asistencial Universitario de Palencia (María Teresa) mfernandezgonz@saludcastillayleon.es
21-23 Febrero NUTERGIA
06-08 Marzo Toledo Ginecología I UCLM (SUNSI) asuncion.ferri@uclm.es
20-22 Marzo NUTERGIA
03-05 Abril Toledo Ginecología II UCLM (SUNSI) asuncion.ferri@uclm.es
17-19 Abril NUTERGIA
02-03 Mayo NUTERGIA
16-17 Mayo NUTERGIA
30-31 Mayo NUTERGIA
12-14 Junio Toledo Master Ginecología UCLM (SUNSI) asuncion.ferri@uclm.es
03-05 Julio A Coruña (SENIN) fjsenin@udc.es
11-13 Septiembre A Coruña (SENIN) fjsenin@udc.es
18-20 Septiembre Cartagena Ginecología I Formaciones Centro Hebamme formacion@centrohebamme.com
16-18 Octubre Cartagena Ginecología II Formaciones Centro Hebamme formacion@centrohebamme.com

cursos 2021


Fechas 2021 Ciudad Tipo de Curso Organizado Contacto Inscripción
15-17 Enero Toledo Básico UCLM (SUNSI) asuncion.ferri@uclm.es
12-14 Febrero Toledo Básico UCLM (SUNSI) asuncion.ferri@uclm.es
12-14 Marzo Toledo Ginecología UCLM (SUNSI) asuncion.ferri@uclm.es
09 -11 Abril Toledo Ginecología UCLM (SUNSI) asuncion.ferri@uclm.es
14-16 Mayo Toledo Master Ginecología UCLM (SUNSI) asuncion.ferri@uclm.es

Interactúa

Hemos creado un grupo de Fisiogenómicos en Facebook para poder tener una relación más cercana con todos aquellos interesados en mejorar su salud a través de los cambios en nutrigenómica. Aquí se podrán compartir dudas y aportaciones de interés para todos. Participa! Cuantas más opiniones y mentes pensando, más aprenderemos todos

pulsa aqui para comentar

Articulos

Sharing knowledge, Accepting challenge.

Busca todos los artículos aquí...

A red meat-derived glycan promotes inflammation and cancer progression. Un glucano derivado de la carne roja promueve la inflamación y la progresión del cáncer

We present an unusual mechanism for the well-known association between red meat consumption and carcinoma risk involving the nonhuman sialic acid N-glycolylneuraminic acid (Neu5Gc). We first evaluate the Neu5Gc content of various foods to show that red meats are particularly rich in orally bioavailable Neu5Gc and then investigate human-like Neu5Gc-deficient mice fed this form of Neu5Gc. When such mice were challenged with anti-Neu5Gc antibodies, they developed evidence of systemic inflammation. Long-term exposure to this combination resulted in a significantly higher incidence of carcinomas (five-fold increase) and an association with Neu5Gc accumulation in the tumors. Similar mechanisms may contribute to the association of red meat consumption with other diseases, such as atherosclerosis and type 2 diabetes, which are also exacerbated by inflammation. ...Leer mas

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Evaluation and treatment of peroneal neuropathy. Evaluación y tratamiento de la neuropatía peronea.

Peroneal nerve compromise results in the clinical complaint of weakness of the ankle dorsiflexors and evertors. This peripheral origin of foot drop has been reported due to numerous traumatic and insidious causes. Traumatic causes of nerve injury occur in association with musculoskeletal injury or with isolated nerve traction, compression, or laceration. Insidious causes include mass lesions and metabolic syndromes. The peroneal nerve is most commonly interrupted at the knee. However, the sciatic and peroneal nerves may be compromised at the hip and ankle as well. This article reviews the anatomical origin of the nerve, the etiologies of possible nerve damage, evaluation of the patient with peroneal nerve injury, and treatment of this disorder. ...Leer mas

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Glycine Improves Biochemical and Biomechanical Properties Following Inflammation of the Achilles Tendon. La glicina mejora las propiedades bioquímicas y biomecánicas después de la inflamación del tendón de Aquiles

Tendinopathy of the Achilles tendon is a clinical problem that motivates the scientific community to search for treatments that assist in restoring its functional properties. Glycine has broad biological effects, acting as a modulator of the inflammatory cascade, and is the predominant amino acid in collagen. A 5% glycine diet provided beneficial effects against toxicity and inflammation since glycine may restructure the collagen molecules faster due to its broad anti‐inflammatory effects. The purpose was analyze the effects of a 5% glycine diet in rats as a treatment for the inflammatory process. The experimental groups were as follows: C (control group), G1 and G3 (inflammatory group), and G2 and G4 (glycine + inflammatory group). G1 and G2 were euthanized 8 days following injury, and G3 and G4 were euthanized 22 days following injury. The concentrations of hydroxyproline, non‐collagenous proteins, and glycosaminoglycans, as well as the activity of MMP‐2 and ‐9 were analyzed. Biomechanical and morphological tests were employed. Higher concentrations of hydroxyproline and glycosaminoglycans were found in G4 and an increased activity of MMP‐2 was found in G2. Higher birefringence was noted in group G2. The biomechanical results indicated that the tendon was more resistant to loading to rupture upon treatment with a glycine diet in group G4. Glycine induced the synthesis of important components of the tendon. A rapid remodeling was noted when compared with the inflamed‐only groups. These data suggest that glycine may be a beneficial supplement for individuals with inflammation of the Achilles tendon. ...Leer mas

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Multifarious Beneficial Effect of Nonessential Amino Acid, Glycine: A Review. Efecto beneficioso multifásico de los aminoácidos no esenciales, la glicina: una revisión

Glycine is most important and simple, nonessential amino acid in humans, animals, and many mammals. Generally, glycine is synthesized from choline, serine, hydroxyproline, and threonine through interorgan metabolism in which kidneys and liver are the primarily involved. Generally in common feeding conditions, glycine is not sufficiently synthesized in humans, animals, and birds. Glycine acts as precursor for several key metabolites of low molecular weight such as creatine, glutathione, haem, purines, and porphyrins. Glycine is very effective in improving the health and supports the growth and well-being of humans and animals. There are overwhelming reports supporting the role of supplementary glycine in prevention of many diseases and disorders including cancer. Dietary supplementation of proper dose of glycine is effectual in treating metabolic disorders in patients with cardiovascular diseases, several inflammatory diseases, obesity, cancers, and diabetes. Glycine also has the property to enhance the quality of sleep and neurological functions. In this review we will focus on the metabolism of glycine in humans and animals and the recent findings and advances about the beneficial effects and protection of glycine in different disease states. ...Leer mas

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Uso de Probióticos para el Control de la Hipercolesterolemia. Use of Probiotics for the Control of Hypercholesterolemia

La hipercolesterolemia es de las principales causas del desarrollo de las enfermedades cardiovasculares, por lo que es importante reducir los niveles de colesterol en sangre. Hay diversas estrategía para reducir la hipercolesterolemia, como son: modificar la conducta alimentaria, hacer ejercicio con regularidad o el tratamiento con fármacos, también se ha propuesto el consumo de los probióticos o bacterias que conforman la microbióta intestinal (MI). Las bacterias probióticas pueden reducir el colesterol por disminuir la absorción del mismo, por la acción de hidrolasa de sales biliares (HSB), por atrapar el colesterol a la membrana de las bacteriana, por la conversión de colesterol a coprostanol, por inhibición de la formación de micelas y por la fermentación selectiva de ciertos alimentos por la microbiota intestinal. Así, el uso de bacterias probióticas es una alternativa para disminuir la hipercolesterolemia y prevenir el desarrollo de enfermedades cardiovasculares, aunque los mecanismos no son completamente claros. ...Leer mas

Cholelithiasis during pregnancy and postpartum: prevalence, presentation and consequences in a Referral Hospital in Baja California Sur. Colelitiasis durante el embarazo y el posparto: prevalencia, presentación y consecuencias en un hospital de referencia en Baja California Sur

Pregnancy and the postpartum period are risk factors for developing biliary sludge, gallstones, and any of their complications. Objective: To determine the prevalence, presentation, and consequences of cholestasis during pregnancy and postpartum in a referral hospital of Baja California Sur. Material and Methods: This was a retrospective, observational study that enrolled pregnant or postpartum patients diagnosed with gallstones with any presentation. Results: 137 patients were included with 22 ± 4 years of age; 33 were pregnant and 104 in the postpartum period. Only 14% of the group had a history of cholelithiasis, and overweight/obesity was observed in 66.7 and 66.3% of pregnant and postpartum patients, respectively (p = 0.94). Of pregnant patients, 33.3% presented with acute cholecystitis, a condition observed in 16.3% of the postpartum patients (p = 0.04). Pancreatitis and choledocholithiasis were slightly more common in pregnant women (21.23% vs. 19.2%; p = 0.56). There was no maternal mortality and one case of spontaneous abortion was exclusively observed. Conclusions: It is a priority to diagnose and monitor cholelithiasis in pregnant women because the acute cases observed occurred more frequently, but choledocholithiasis and pancreatitis occurred similarly in both groups. QOL of the AR patients. ...Leer mas

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The interactive correlation of pain, negative emotion, insomnia and quality of life in Allergic Rhinitis patients. La correlación interactiva de dolor, emoción negativa, Insomnio y calidad de vida en pacientes con rinitis alérgica.

Objective: To investigate the pain characteristics, physiological and psychological symptoms, as well as quality of life (QOL) in Allergic Rhinitis (AR) patients suffering from chronic pain and to analyze the influential factors on QOL. Methods: 122 AR patients and 102 normal subjects were participated in this study. The pain characteristics, QOL, depression, anxiety and insomnia were evaluated respectively. All the data were put into statistical software and t-test was used to analyze the difference. Pearson correlation analysis, multiple linear stepwise regression analysis and path analysis were used in the data analysis. Results: SF-MPQ total score, sensory pain sub-score, and the emotional pain sub-score were positively correlated with BDI, BAI, AIS total scores in the patient group. Furthermore, there existed a statically significant negative correlation between SF-12 subsets and characteristic of pain, depression, anxiety, insomnia in the cancer pain patients. Conclusion: The depression, anxiety and insomnia of the AR patients were significantly in higher levels than that of the normal population and thereby their QOL was also lower than the control group. Depression and anxiety were the most obvious influential factors affected the QOL of the AR patients. ...Leer mas

Exercise-induced rhabdomyolysis mechanisms and prevention: A literature review. Mecanismos y prevención de la rabdomiolisis inducida por el ejercicio: revisión de la literatura.

Exercise-induced rhabdomyolysis (exRML), a pathophysiological condition of skeletal muscle cell damage that may cause acute renal failure and in some cases death. Increased Ca2+ level in cells along with functional degradation of cell signaling system and cell matrix have been suggested as the major pathological mechanisms associated with exRML. The onset of exRML may be exhibited in athletes as well as in general population. Previous studies have reported that possible causes of exRML were associated with excessive eccentric contractions in high temperature, abnormal electrolytes balance, and nutritional deficiencies possible genetic defects. However, the underlying mechanisms of exRML have not been clearly established among health professionals or sports medicine personnel. Therefore, we reviewed the possible mechanisms and correlated prevention of exRML, while providing useful and practical information for the athlete and general exercising population. ...Leer mas

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Diet and fertility: a review. Dieta y fertilidad: una revisión.

The literature on the relationship between diet and human fertility has greatly expanded over the last decade, resulting in the identification of a few clear patterns. Intake of supplemental folic acid, particularly at doses higher than those recommended for the prevention of neural tube defects, has been consistently related to lower frequency of infertility, lower risk of pregnancy loss, and greater success in infertility treatment. On the other hand and despite promising evidence from animal models, vitamin D does not appear to exert an important role in human fertility in the absence of deficiency. Antioxidant supplementation does not appear to offer any benefits to women undergoing infertility treatment, but it appears to be beneficial when it is the male partner who is supplemented. However, the available evidence does not allow discerning which specific antioxidants, or at which doses, are responsible for this benefit. Long-chain omega-3 fatty acids appear to improve female fertility, although it remains unclear to what extent contamination of shared food sources, such as fish with high levels of environmental toxicants, can dampen this benefit. Lastly, adherence to healthy diets favoring seafood, poultry, whole grains, fruits, and vegetables are related to better fertility in women and better semen quality in men. The cumulative evidence has also piled against popular hypotheses. Dairy and soy, once proposed as reproductive toxicants, have not been consistently related to poor fertility. In fact, soy and soy supplements appear to exert a beneficial effect among women undergoing infertility treatment. Similarly, because data from large, high-quality studies continue to accumulate, the evidence of a potentially deleterious effect of moderate alcohol and caffeine intake on the ability to become pregnant seems less solid than it once did. While a complete picture of the role of nutrition on fertility is far from complete, much progress has been made. The most salient gaps in the current evidence include jointly considering female and male diets and testing the most consistent findings in randomized trials. ...Leer mas

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A correlation between intestinal microbiota dysbiosis and osteoarthritis. Una correlación entre la microbiosis disbiosis intestinal y la artrosis.

Osteoarthritis (OA) is a degenerative disease of the articular cartilage, resulting in pain and total joint disability. Recent studies focused on the role of the metabolic syndrome in inducing or worsening joint damage suggest that chronic low-grade systemic inflammation may represent a possible linking factor. This finding supports the concept of a new phenotype of OA, a metabolic OA. The gut microbiome is fundamental for human physiology and immune system development, among the other important functions. Manipulation of the gut microbiome is considered an important topic for the individual health in different medical fields such as medical biology, nutrition, sports, preventive and rehabilitative medicine. Since intestinal microbiota dysbiosis is strongly associated with the pathogenesis of several metabolic and inflammatory diseases, it is conceivable that also the pathogenesis of OA might be related to it. However, the mechanisms and the contribution of intestinal microbiota metabolites in OA pathogenesis are still not clear. The aim of this narrative review is to review recent literature concerning the possible contribution of dysbiosis to OA onset and to discuss the importance of gut microbiome homeostasis maintenance for optimal general health preservation. ...Leer mas

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Advanced glycation end products-induced insulin resistance involves repression of skeletal muscle GLUT4 expression. La resistencia a la insulina inducida por productos finales de glicación avanzada implica la represión de la expresión GLUT4 del músculo esquelético

Little is known about advanced glycation end products (AGEs) participation in glucose homeostasis, a process in which skeletal muscle glucose transporter GLUT4 (Scl2a4 gene) plays a key role. This study investigated (1) the in vivo and in vitro effects of AGEs on Slc2a4/GLUT4 expression in skeletal muscle of healthy rats, and (2) the potential involvement of endoplasmic reticulum and inflammatory stress in the observed regulations. For in vivo analysis, rats were treated with advanced glycated rat albumin (AGE-albumin) for 12 weeks; for in vitro analysis, soleus muscles from normal rats were incubated with bovine AGE-albumin for 2.5 to 7.5 hours. In vivo, AGE-albumin induced whole-body insulin resistance; decreased (~30%) Slc2a4 mRNA and GLUT4 protein content; and increased (~30%) the nuclear content of nuclear factor NF-kappa-B p50 subunit (NFKB1), and cellular content of 78 kDa glucose-regulated protein (GRP78). In vitro, incubation with AGE-albumin decreased (~50%) the Slc2a4/GLUT4 content; and increased cellular content of GRP78/94, phosphorylated-IKK-alpha/beta, nuclear content of NFKB1 and RELA, and the nuclear protein binding into Slc2a4 promoter NFKB-binding site. The data reveal that AGEs impair glucose homeostasis in non-diabetic states of increased AGEs concentration; an effect that involves activation of endoplasmic reticulum- and inflammatory-stress and repression of Slc2a4/GLUT4 expression. ...Leer mas

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Tendinopathy. Tendinopatía.

Chronic tendon injuries are a common cause of pain and of restriction of sports or daily life. Even though a number of published studies have focused on tendon injuries, healing and treatment, the pathogenesis still remains enigmatic. The pathogenesis of chronic tendon injuries is considered multifactorial, however the precise role of each predisposing factor remains incompletely understood ...Leer mas

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Chronic pain as a symptom or a disease the IASP Classification of Chronic Pain for the International Classification of Diseases (ICD-11). El dolor crónico como síntoma o enfermedad. la Clasificación IASP del dolor crónico para la Clasificación Internacional de Enfermedades (ICD-11)

Pain is one of the most frequent causes for patients to seek medical care.28 Although mortality rates are highest for cardiac infarction and stroke, infectious diseases, cancers, and diabetes, chronic pain is a leading source of human suffering and disability.18 Pain itself and many diseases associated with chronic pain are not immediately life threatening; people continue to live with their pain, and hence, these conditions are common in both developed and developing countries.8,11 The Global Burden of Disease Study 2013 evaluated “years lived with disability” (YLDs: the prevalence multiplied by a disability-weighting factor) for a broad range of diseases and injuries in 188 countries.34 The single greatest cause of YLDs around the world was chronic low-back pain, followed by major depressive disorder. Other frequent causes of YLDs include chronic neck pain, migraine, osteoarthritis, other musculoskeletal disorders, and medication overuse headache. ...Leer mas

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The Small Intestine Converts Dietary Fructose into Glucose and Organic Acids. El intestino delgado convierte la fructosa dietética en glucosa y ácidos orgánicos

Excessive consumption of sweets is a risk factor for metabolic syndrome. A major chemical feature of sweets is fructose. Despite strong ties between fructose and disease, the metabolic fate of fructose in mammals remains incompletely understood. Here we use isotope tracing and mass spectrometry to track the fate of glucose and fructose carbons in vivo, finding that dietary fructose is cleared by the small intestine. Clearance requires the fructose-phosphorylating enzyme ketohexokinase. Low doses of fructose are ∼90% cleared by the intestine, with only trace fructose but extensive fructose-derived glucose, lactate, and glycerate found in the portal blood. High doses of fructose (≥1 g/kg) overwhelm intestinal fructose absorption and clearance, resulting in fructose reaching both the liver and colonic microbiota. Intestinal fructose clearance is augmented both by prior exposure to fructose and by feeding. We propose that the small intestine shields the liver from otherwise toxic fructose exposure. ...Leer mas

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Hypothyroidism and its Effect on Menstrual Pattern and Fertility. Hipotiroidismo y su efecto sobre el patrón menstrual y la fertilidad.

Hypothyroidism is one of the most common endocrine disorders encountered in clinical practice. Thyroid disorder is very common among the female. The aim of this study was to evaluate the effects of hypothyroidism on menstrual pattern and sub-fertility. This cross-sectional comparative study was carried out in the Department of Obstetrics and Gynecology with collaboration of endocrine department of Bangabandhu Sheikh Mujib Medical University (BSMMU) from July 2006 to June 2008, cases were collected from the thyroid clinic of this hospital. Total study subject were 139, among them hypothyroid cases were 79 and euthyroid were 60. Among the hypothyroidism group 62.0% (n=49) had normal menstrual cycle, 21.5% (n=16) had oligomenorrhoea, 10.1% (n=8) had polymenorrhoea and 6.3% (n=6) had amenorrhoea. On the contrary in euthyroid group 86.7% (n=52) had normal menstrual cycle, 6.7% (n=4) had oligomenorrhoea, 5.0% (n=3) had polymenorrhoea and 1.7% (n=1) had amenorrhoea. Proportion of abnormal menstrual history was found to high among hypothyroid group almost 34% (n=27) compared to euthyroid group 13.4% (n=8) and the difference was statistically significant (p<0.001). The proportion of primary subfertility in hypothyroid 11.4% (n=9) whereas in euthyroid cases 1.7% (n=1) and secondary subfertility in hypothyroid 7.6% (n=6) where as in euthyroid cases 5.0% (n=3). So, sub-fertility was higher among hypothyroid group compared to euthyroid group but the difference was not statistically significant (p>0.05). Overall sub-fertility was 13.7% (n=10) and it was 6.7% (n=4) among the euthyroid group. Among total hypothyroid group 60.7% (n=48) are the overt hypothyroid and 39.20% (n=31) are the sub-clinical hypothyroid group. The effect of hypothyroidism is significant on menstrual pattern and on fertility. Hypothyroid women had more menstrual disorders and also suffering from sub-fertility. ...Leer mas

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